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Representative Publications for William Dunphy
- Dunphy, W.G., and Kumagai, A. (1991). The Cdc25 protein contains an intrinsic phosphatase activity. Cell 67:189-196.
- Mueller, P.R., Coleman, T.R., Kumagai, A., and Dunphy, W.G. (1995). Myt1: A membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science 270:86-90.
- Kumagai, A., and Dunphy W.G. (1996). Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. Science 273:1377-1380.
- Kumagai, A., and Dunphy, W.G. (2000). Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol. Cell 6:839-849.
- Guo, Z., Kumagai, A., Wang, S.X., and Dunphy, W.G. (2000). Requirement for ATR in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes and Development 14:2745-2756.
- Lee, J., Kumagai, A., and Dunphy, W.G. (2003). Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol. Cell 11:329-340.
- Yoo, H.Y., Kumagai, A., Shevchenko, A, Shevchenko, A., and Dunphy, W.G. (2004). Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell 117:575-588.
- Kumagai, A., Lee, J., Yoo, H.Y., and Dunphy, W.G. (2006). TopBP1 activates the ATR-ATRIP complex. Cell 124:943-955.
- Yoo, H.Y., Jeong, S.-Y., and Dunphy, W.G. (2006). Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures. Genes and Development 20:772-783.
- Lee, J., Kumagai, A., and Dunphy, W.G. (2007). The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J. Biol. Chem. 282:28036-28044.
