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CURRICULUM VITAE

Ellen V. Rothenberg

Address (work): Division of Biology, 156-29 California Institute of Technology Pasadena, California 91125 Phone: (626) 395-4992 FAX No.: (626) 449-0756 or (626) 584-9075 E-mail: evroth@its.caltech.edu

Education:

Harvard University, Cambridge, Massachusetts September 1969-June 1972, A.B. summa cum laude in Biochemical Sciences, 1972; Harvard University--Massachusetts Institute of Technology, Boston, Massachusetts September 1972-January 1973 Joint program in Health Sciences and Technology, Courses toward M.D.; Massachusetts Institute of Technology, Cambridge, Massachusetts, Department of Biology and Center for Cancer Research, September 1972-January 1977 Ph.D. in Cell Biology, 1977 (advisor: David Baltimore); Memorial Sloan-Kettering Cancer Center, New York, New York, Department of Cell Surface Immunogenetics, November 1977-September 1979, Postdoctoral (advisor: Edward A. Boyse).

Positions Held:

Teaching Assistant--Massachusetts Institute of Technology, General Biology (supervisor: Salvador Luria) February 1974-June 1974; NSF Predoctoral Research Fellow—MIT, September 1973-August 1976; Research Associate--Center for Cancer Research, Massachusetts Institute of Technology (advisor: David Baltimore), February 1977-October 1977; Postdoctoral Research Fellow--Memorial Sloan-Kettering Cancer Center, New York, New York, November 1977-September 1979; Assistant Research Professor--The Salk Institute for Biological Studies, Department of Cancer Biology, September 1979-May 1982; Assistant Professor of Biology--California Institute of Technology, Division of Biology, Pasadena, California, June 1982-June 1988; Associate Professor of Biology--California Institute of Technology, Division of Biology, Pasadena, California, July 1988-August 1994. Professor of Biology--California Institute of Technology, Division of Biology, Pasadena, CA, September 1994-present; Albert Billings Ruddock Professor of Biology—California Institute of Technology, Division of Biology, Pasadena, CA, April 2007-present.

Honors and Awards:

National Merit Scholar, 1969; Phi Beta Kappa, 1971; A.B. summa cum laude, Harvard University, 1972; National Science Foundation Predoctoral Fellowship, 1973-1976; Jane Coffin Childs Memorial Fund for Medical Research Postdoctoral Fellowship, 1977-1979; Biology Undergraduate Students Advisory Council Award for excellence in teaching, 1988; Ferguson Prize for Undergraduate Teaching, 1995; Associated Students of Caltech (ASCIT) Award for Excellence in Undergraduate Teaching, 1998; Ferguson Prize for Undergraduate Teaching, 1999; Biology Undergraduate Students Advisory Committee Award for Excellence in Teaching, 2001; Biology Undergraduate Students Advisory Committee Award for Excellence in Teaching, 2003-2004; Associated Students of Caltech (ASCIT) Award for Excellence in Undergraduate Teaching, 2007.

Professional Societies:

American Association of Immunologists (active); American Society for Microbiology (former); Sigma Xi (former); AAAS (active); New York Academy of Sciences (former)

Committee Memberships and Editorial Boards:

Council Member--Midwinter Conference of Immunologists, 1/1981-1/1986; Member of review committee--American Cancer Society (California Division) Postdoctoral Fellowship Program, 9/1982-8/1985; Associate Editor, Journal of Molecular and Cellular Immunology, 1984-; Associate Editor, Journal of Immunology, 7/1986-6/1991; Associate Editor, Molecular Reproduction and Development, 1987-1997; Member, Awards Committee, American Association of Immunologists, 7/1986-6/1989; Member, Immunological Sciences Study Section, Division of Research Grants, National Institutes of Health/Public Health Service, 9/1988-6/1992; Program (Block) Chairman, American Association of Immunologists, T Cells (Block B), 1989-1992; Member of review committee--American Cancer Society (California Division) Postdoctoral Fellowship Screening Panel, 9/1992-7/1995 (2nd term); American Institute of Biological Sciences Scientific Working Group and Peer Review Panel to NASA: Physiological and Anatomical Rodent Experiment.04, 1992-1994; Member, Scientific Advisory Board, Hereditary Disease Foundation, 5/1991-2/1995; Member, NIAID-NIA Task Force on Immunology and Aging, 1994; International Union of Immunology Societies designated reporter for 9th International Congress of Immunology, 1995; Member, National Research Council panel for review of Howard Hughes Medical Institute Predoctoral Fellowships in the Biological Sciences, 1996; Faculty, American Association of Immunologists Advanced Course in Immunology, July 1996; Editorial Board Member, Journal of Clinical Immunology, 1997-2000; Editorial Board Member, Developmental and Comparative Immunology, 1997-2000; Member, External Advisory Board, The Lerner Research Institute (Cancer Center), Cleveland Clinic Foundation, 1997-2003; Founding organizer, Aegean Conference on Gene Regulation in Lymphocyte Development, and co-chairman, 2002-2004; Faculty, Japanese Society for Immunology summer immunology course, 2004; Section Editor, Journal of Immunology, 2004-2006; Associate Editor, Immunity, January 2005 – present. Scientific Advisory Board, La Jolla Institute for Allergy and Immunology: 2005 – present. Faculty, AAI Advanced Immunology Course, July 2005, July 2006. Program (Block) Co-Chairman, American Association of Immunologists, Hematopoiesis and Immune System Development, 2007-2010.

Site visitor and ad hoc reviewer for NCI, NIA, and CSR (NIH); NASA; other agencies

Publications:

  1. Rothenberg, E. and D. Baltimore. 1976. Synthesis of long, representative DNA copies of the murine RNA tumor virus genome. J. Virol. 17, 168-174.
  2. Haseltine, W. A., D. G. Kleid, A. Panet, E. Rothenberg and D. Baltimore. 1976. Ordered transcription of RNA tumor virus genomes. J. Mol. Biol. 106, 109-131.
  3. Rothenberg, E. and D. Baltimore. 1977. Increased length of DNA made by virions of murine leukemia virus at limiting magnesium ion concentration. J. Virol. 21, 168-178.
  4. Rothenberg, E., D. Smotkin, D. Baltimore and R. A. Weinberg. 1977. In vitro synthesis of infectious DNA of murine leukemia virus. Nature (London) 269, 122-126.
  5. Rothenberg, E., D. J. Donoghue and D. Baltimore. 1978. Analysis of a 5' leader sequence on murine leukemia virus 21S RNA; heteroduplex mapping with long reverse transcriptase products. Cell 13, 435-451.
  6. Donoghue, D. J., E. Rothenberg, N. Hopkins, D. Baltimore and P. A. Sharp. 1978. Heteroduplex analysis of the nonhomology region between Moloney MuLV and the dual host range derivative HIX virus. Cell 14, 959-970.
  7. Shields, A., O. N. Witte, E. Rothenberg and D. Baltimore. 1978. High frequency of aberrant expression of Moloney murine leukemia virus in clonal interactions. Cell 14, 601-609.
  8. Baltimore, D., E. Gilboa, E. Rothenberg and F. Yoshimura. 1979. Production of a discrete infectious, double-stranded DNA by reverse transcription in virions of Moloney leukemia virus. Cold Spring Harbor Symp. in Quant. Biol. 43, 869-874.
  9. Rothenberg, E. and E. A. Boyse. 1979. Synthesis and processing of molecules bearing thymus leukemia antigen. J. Exp. Med. 150, 777-791.
  10. Rothenberg, E. 1980. Expression of differentiation antigens in subpopulations of mouse thymocytes: regulation at the level of de novo synthesis. Cell 20, 1-9.
  11. Michaelson, J., E. Rothenberg and E. A. Boyse. 1980. Genetic polymorphism of murine beta2-microglobulin detected biochemically. Immunogenetics 11, 93-95.
  12. Rothenberg, E. and D. Triglia. 1980. In vitro maintenance of differentiation marker synthesis by subpopulations of mouse thymocytes. Proc. 1980 ICN-UCLA Symp. on Control of Cellular Division and Development and J. Supramolec. Struct. 14, 371-382.
  13. Triglia, D. and E. Rothenberg. 1981. "Mature" thymocytes are not glucocorticoid- resistant in vitro. J. Immunol. 127, 64-68.
  14. Rothenberg, E. and D. Triglia. 1981. Structure and expression of glycoproteins controlled by the Qa-1a allele. Immunogenetics 14, 455-468.
  15. Rothenberg, E. 1982. A specific biosynthetic marker for immature thymic lymphoblasts: active synthesis of thymus-leukemia antigen restricted to proliferating cells. J. Exp. Med. 155, 140-154.
  16. Rothenberg, E. 1982. What is the role of T-lymphocyte surveillance in neoplastic disease? Am. J. Surgery 143, 664-669.
  17. Rothenberg, E. and D. Triglia. 1983. Lyt-2 glycoprotein is synthesized as a single molecular species. J. Exp. Med. 157, 365-370.
  18. Rothenberg, E. and D. Triglia. 1983. Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice. J. Immunol. 130, 1627-1633.
  19. Rothenberg, E., B. Caplan, J. Trotter and D. Triglia. 1984. Thymic lymphoblasts: heterogeneity and developmental fates. In Recognition and Regulation in Cell-Mediated Immunity. J. D. Watson and J. Marbrook (Eds.). Marcel Dekker, Inc., New York, pp. 61-86.
  20. Caplan, B. and E. Rothenberg. 1984. High-level secretion of interleukin-2 by a subset of proliferating thymic lymphoblasts. J. Immunol. 133, 1983-1991.
  21. Haas, M., A. Altman, E. Rothenberg, M. H. Bogart and O. W. Jones. 1984. Mechanism of T-cell lymphomagenesis: transformation of growth-factor-dependent T-lymphoblastoma cells to growth-factor-independent T-lymphoma cells. Proc. Natl. Acad. Sci. USA 81, 1742-1746.
  22. Rothenberg, E., B. Caplan and R. D. Sailor. 1984. Toward a molecular basis for growth control in T-lymphocyte development. In Molecular Biology of Development. UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 19. E. H. Davidson and R. A. Firtel (Eds.). Alan R. Liss, Inc., New York, pp. 511-525.
  23. Lugo, J. P., S. N. Krishnan, R. D. Sailor, P. Koen, T. Malek and E. Rothenberg. 1985. Proliferation of thymic stem cells with and without receptors for interleukin-2: implications for intrathymic antigen recognition. J. Exp. Med., 161, 1048-1062.
  24. Rothenberg, E. and J. P. Lugo. 1985. Differentiation and cell division in the mammalian thymus. Dev. Biol. 112, 1-17.
  25. Lugo, J. P., S. N. Krishnan, R. Diamond Sailor and E. V. Rothenberg. 1986. Early precursor thymocytes can produce interleukin 2 upon stimulation with calcium ionophore and phorbol ester. Proc. Natl. Acad. Sci. USA 83, 1862-1866.
  26. Novak, T. J. and E. V. Rothenberg. 1986. Differential transient and long-term expression of DNA sequences introduced into T lymphocyte lines. DNA 5, 439-451.
  27. Kinnon C., R. A. Diamond and E. Rothenberg. 1986. Activation of T-cell antigen receptor  and  chain genes in the thymus. Implications for the lineages of developing cortical thymocytes. J. Immunol. 137, 4010-4015.
  28. Rothenberg, E. V., C. Kinnon, K. L. McGuire, J. P. Lugo and R. A. Diamond. 1987. Activation of receptor and response genes in T lymphocyte development. In Molecular Approaches to Developmental Biology, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 51. R. A. Firtel and E. H. Davidson (Eds.). Alan R. Liss, Inc., New York, pp. 453-467.
  29. Haas, M., A. Altman, E. Rothenberg, M. H. Bogart and O. W. Jones. 1987. Radiation leukemia virus and x-irradiation induce in C57BL/6 mice two distinct T-cell neoplasms: a growth factor-dependent lymphoma and a growth factor-independent lymphoma. Leukemia Res. 11, 223-239.
  30. McGuire, K. L. and E. V. Rothenberg. 1987. Inducibility of interleukin-2 (IL2) RNA expression in individual mature and immature T lymphocytes. EMBO J. 6, 939-946.
  31. Kinnon, C., K. L. McGuire and E. V. Rothenberg. 1987. Differential regulation of T-cell receptor gamma genes in immature thymocyte populations. Eur. J. Immunol. 17, 1265-1269.
  32. Boyer, P. D. and E. V. Rothenberg. 1988. Interleukin-2 receptor inducibility is blocked in cortical-type thymocytes. J. Immunol. 140, 2886-2892.
  33. McGuire, K. L., J. A. Yang and E. V. Rothenberg. 1988. Influence of activating stimulus on functional phenotype: interleukin-2 mRNA accumulation differentially induced by ionophore and receptor ligands in subsets of murine T cells. Proc. Natl. Acad. Sci. USA 85, 6503-6507.
  34. Rothenberg, E. V., K. L. McGuire, and P. D. Boyer. 1988. Molecular indices of functional competence in developing T cells. Immunol. Rev. 104, 29-53.
  35. Boyer, P. D., R. A. Diamond and E. V. Rothenberg. 1989. Changes in inducibility of interleukin-2 receptor alpha chain and T-cell receptor expression during thymocyte differentiation in the mouse. J. Immunol.142, 4121-4130.
  36. Rothenberg, E. V. 1989. The long road to functional maturity for developing T cells. Immunology Today 10, 116-117.
  37. Rothenberg, E. V. and D. DeLuca. 1990. Discussion summary: Lymphocyte evolution and development. In Defense Molecules, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 121. J. J. Marchalonis and C. Reinisch (Eds.). Alan R. Liss, Inc., New York, pp. 235-239.
  38. Rothenberg, E. V., R. A. Diamond, K. A. Pepper and J. A. Yang. 1990. Interleukin-2 gene inducibility in T cells prior to T-cell receptor expression: changes in signaling pathways and gene expression requirements during intrathymic maturation. J. Immunol. 144, 1614-1624.
  39. Rothenberg, E. V., R. A. Diamond, T. J. Novak, K. A. Pepper and J. A. Yang. 1990. Mechanisms of effector lineage commitment in T lymphocyte development. In Developmental Biology, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 125. E. H. Davidson, J. Ruderman and J. Posakony (Eds.). Alan R. Liss, Inc., New York, pp. 225-249.
  40. Rothenberg, E. V. 1990. Death and transfiguration of cortical thymocytes: A reconsideration. Immunol. Today 11, 116-119.
  41. Novak, T. J., P. M. White, and E. V. Rothenberg. 1990. Regulatory anatomy of the murine interleukin-2 gene. Nucl. Acids Res.18, 4523-4533.
  42. Rothenberg, E. V. 1990. Developmental shifts in signaling pathways for lymphokine production and growth response. In Forum on Interleukins and T-Cell Development, C. Martinez-A., (Ed.). Research in Immunology 141, 289-293.
  43. Novak, T. J. and E. V. Rothenberg. 1990. cAMP inhibits induction of IL2 but not of IL4 in T cells. Proc. Natl. Acad. Sci. USA 87, 9353-9357.
  44. Novak, T. J., D. Chen, and E. V. Rothenberg. 1990. Interleukin 1 synergy with phosphoinositide pathway agonists for induction of interleukin 2 gene expression: Molecular basis of costimulation. Mol. Cell. Biol.10, 6325-6334.
  45. Rothenberg, E. V., D. Chen, R. A. Diamond, M. Dohadwala, T. J. Novak, P. M. White, and J. A. Yang-Snyder. 1991. Acquisition of mature functional responsiveness in T cells: Programming for function via signaling. In: Mechanisms of Lymphocyte Activation and Immune Regulation III, S. Gupta, W. C. Paul, M. D. Cooper, and E. V. Rothenberg (Eds.). Plenum Publishing Corp., New York, NY, pp. 71-83.
  46. Rothenberg, E. V. 1991. Cell separation and analysis: a strategic overview. Methods: A Companion to Methods in Enzymology 2, 168-172.
  47. Novak, T. J., F. K. Yoshimura, and E. V. Rothenberg. 1992. In vitro transfection of fresh thymocytes and T cells shows subset-specific expression of viral promoters. Mol. Cell. Biol. 12, 1515-1527.
  48. Rothenberg, E. V. 1992. The development of functionally responsive T cells. Adv. Immunol. 51, 85-214.
  49. Chen, D. and E. V. Rothenberg. 1993. Molecular basis for developmental changes in interleukin-2 gene inducibility. Mol. Cell. Biol. 13, 228-237.
  50. Yang-Snyder, J. A. and E. V. Rothenberg. 1993. Developmental and anatomical patterns of IL 2 gene expression in vivo in the murine thymus. Devel. Immunol. 3, 85-102.
  51. Rothenberg, E. V., D. Chen, and R. A. Diamond. 1993. Functional and phenotypic analysis of thymocytes in SCID mice: evidence for functional response transitions before and after the SCID arrest point. J. Immunol. 151, 3530-3546.
  52. Garrity, P. A., D. Chen, E. V. Rothenberg and B. J. Wold. 1994. IL 2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors. Mol. Cell. Biol. 14, 2159-2169.
  53. Rothenberg, E. V. and R. A. Diamond. 1994. Costimulation by interleukin-1 of multiple activation responses in a developmentally restricted subset of immature thymocytes. Eur. J. Immunol. 24, 24-33.
  54. Chen, D. and E. V. Rothenberg. 1994. Interleukin-2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles. J. Exp. Med.179, 931-942.
  55. Rothenberg, E. V. 1994. Signaling mechanisms in thymocyte selection. Curr. Opin. Immunol. 6, 257-265.
  56. Rothenberg, E. V., R. A. Diamond, and D. Chen. 1994. Programming for recognition and programming for response: separate developmental subroutines in the murine thymus. Thymus 22, 215-244.
  57. Lindenboim, L., R. Diamond, E. Rothenberg, and R. Stein. 1995. Apoptosis induced by serum-deprivation of PC12 cells is not preceded by growth arrest and can occur at each phase of the cell cycle. Cancer Res. 55, 1242-1247.
  58. Scherer, L. J., R. A. Diamond, and E. V. Rothenberg. 1995. Developmental regulation of cAMP signaling pathways in thymocyte development. Thymus 23, 231-257.
  59. Reya, T., J. A. Yang-Snyder, E. V. Rothenberg, and S. R. Carding. 1996. Regulated expression and function of IL2/IL15R-beta (CD122) during lymphoid development. Blood 87, 190-201.
  60. Rothenberg, E. V. 1995. Developmental biology of lymphocytes. The Immunologist 3, 172-175.
  61. Rothenberg, E. V. and Ward, S. B. 1996. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin-2 gene regulation. Proc. Natl. Acad. Sci. USA 93, 9358-9365.
  62. Rothenberg, E. V. 1996. How T cells count. Science 273, 78-79.
  63. Diamond, R. A., Ward, S. B., Owada-Makabe, K., Wang, H., and Rothenberg, E. V. 1997. Different developmental arrest points in RAG 2-/- and scid thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangement. J. Immunol. 158, 4052-4064.
  64. Yang-Snyder, J. A., and Rothenberg, E. V. 1998. Spontaneous expression of interleukin-2 in vivo in specific tissues of young mice. Devel. Immunol. 5, 223-245.
  65. Wang, H., Diamond, R. A., and Rothenberg, E. V. 1998. Cross-lineage expression of Ig-beta (B29) in thymocytes: positive and negative gene regulation to establish T-cell identity. Proc. Natl. Acad. Sci. USA 95, 6831-6836.
  66. Rothenberg, E. V. 1998. Gene regulation in T-cell lineage commitment. In: Molecular Biology of B-Cell and T-Cell Development, J. G. Monroe and E. V. Rothenberg (Eds.)., Humana Press, Totowa, NJ, pp.337-365.
  67. Ward, S. B., Hernandez-Hoyos, G., Chen, F., Waterman, M., Reeves, R., and Rothenberg, E. V. 1998. Chromatin remodeling of the interleukin-2 gene: distinct alterations in the proximal versus distal enhancer regions. Nucl. Acids Res. 26, 2923-2934.
  68. Wang, H., Diamond, R. A., Yang-Snyder, J. A., and Rothenberg, E. V. 1998. Precocious expression of T-cell functional response genes in vivo in primitive thymocytes before T lineage commitment. Int. Immunol. 10, 1623-1635.
  69. Chen, F., Chen, D., and Rothenberg, E. V. 1999. Specific regulation of Fos family transcription factors in thymocytes at two developmental checkpoints. Int. Immunol. 11, 677-688.
  70. Rothenberg, E. V., Telfer, J. C., and Anderson, M. K. 1999. Transcriptional regulation of lymphocyte lineage commitment. BioEssays 21, 726-742.
  71. Anderson, M. K. and Rothenberg, E. V. 2000. Transcription factor expression in lymphocyte development: Clues to the evolutionary origins of lymphoid cell lineages? Curr. Top. Microbiol. Immunol. 248, 137-155.
  72. Anderson, M. K., Hernandez-Hoyos, G., Diamond, R. A., and Rothenberg, E. V. 1999. Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage. Development 126, 3131-3148.
  73. Hernandez-Hoyos, G., Sohn, S. J., Rothenberg, E. V., and Alberola-Ila, J. 2000. Lck activity controls CD4/CD8 T-cell lineage commitment. Immunity 12, 313–322.
  74. Rothenberg, E. V., Ward, S. B., Yui, M., Hernandez-Hoyos, G., Chen, F., Bardhan, S., Chen, R., Hotz, R., and Yang-Snyder, J. A. 2001. Developmental specificity of interleukin-2 expression. In: S. Umlauf & B. Beverly, eds. Interleukin-2 (IL 2) Transcription. Landes Biosciences, Austin, TX & eurekah.com.
  75. Telfer, J. C. and Rothenberg, E. V. 2001. Expression and function of a stem-cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development. Devel. Biol. 229, 363-382.
  76. Rothenberg, E. V. 2000. Stepwise specification of lymphocyte developmental lineages. Curr. Opin. Genet. Dev. 10, 370-379.
  77. Yui, M. A., Hernandez-Hoyos, G., and Rothenberg, E. V. 2001. A new regulatory region of the murine IL 2 locus that confers position-independent transgene expression. J. Immunol. 166, 1730-1739.
  78. Makita, T., Hernandez-Hoyos, G., Chen, T. H.-P., Wu, H., Rothenberg, E. V., and Sucov, H. M. 2001. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Genes Dev. 15, 912-924.
  79. Chen, F., Rowen, L., Hood, L., and Rothenberg, E. V. 2001. Differential transcriptional regulation of individual T-cell receptor Vbeta segments before gene rearrangement. J. Immunol. 166, 1771-1780.
  80. Anderson, M. K., Sun, X., Miracle, A. L., Litman, G. W., and Rothenberg, E. V. 2001. Evolution of hematopoiesis: three members of the PU.1 transcription factor family in a cartilaginous fish, Raja eglanteria. Proc. Natl. Acad. Sci. USA 98, 553-558.
  81. Miracle, A. L., Anderson, M. K., Litman, R. T., Walsh, C. J., Luer, C. A., Rothenberg, E. V., and Litman, G. W. 2001. Complex expression patterns of lymphocyte-specific genes during the development of cartilaginous fish implicate unique lymphoid tissues in generating an immune repertoire. Int. Immunol. 13, 567-580.
  82. Rothenberg, E. V. 2001. Notchless T cell maturation?. Nature Immunol. 2, 189-190.
  83. Rothenberg, E. V. 2001. Commentary: Mapping of complex regulatory elements by pufferfish/zebrafish transgenesis. Proc. Natl. Acad. Sci. USA 98, 6540-6542.
  84. Anderson, M. K., Weiss, A. H., Hernandez-Hoyos, G., Dionne, C. J., and Rothenberg, E. V. 2002. Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage. Immunity 16, 285-296.
  85. Rothenberg, E. V. and Davidson, E. H. 2002. Regulatory cooptions in the evolution of the immune systems of the deuterostomes. In: R. A. B. Ezekowitz & J. A. Hoffmann (eds.) Innate Immunity. Humana Press, Totowa, N. J. pp. 61-87.
  86. Rothenberg, E. V. and Anderson, M. K. 2002. Elements of transcription factor network design for T-lineage specification. Devel. Biol. 246, 29-44.
  87. Anderson, M. K., Hernandez-Hoyos, G., Dionne, C. J., Arias, A. M., Chen, D., and Rothenberg, E. V. 2002. Definition of regulatory network elements for T-cell development by perturbation analysis with PU.1 and GATA-3. Devel. Biol. 246, 103-121.
  88. Rothenberg, E. V. 2002. T lineage specification and commitment: a gene regulation perspective. Semin. Immunol. 14, 431-440.
  89. Rothenberg, E. V., Telfer, J. D., and Yui, M. A. 2003. T cell developmental biology. In: W. E. Paul (ed.) Fundamental Immunology, 5th Edition. Lippincott/Williams & Wilkins. Chapter 9, pp. 259-301.
  90. Rothenberg, E. V. and Dionne, C. J. 2002. Lineage plasticity and commitment in T-cell development. Immunol. Rev. 187, 96-115.
  91. Hernández-Hoyos, G., Anderson, M. K., Wang, C., Rothenberg, E. V., and Alberola-Ila, J. 2003. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity 19, 83-94.
  92. Warren, L. A. and Rothenberg, E. V. 2003. Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors. Curr. Opin. Immunol. 15, 166-175.
  93. Yui, M. A., Sharp, L. L., Havran, W. L., and E. V. Rothenberg. 2004. Preferential activation of an Interleukin-2 (IL-2) regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation. J. Immunol. 172, 4691-4699.
  94. Telfer, J. C., Hedblom, E. E., Anderson, M. K., Laurent, M. N., and Rothenberg, E. V. 2004. Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes. J. Immunol. 172, 4359-4370.
  95. Anderson, M. K., Pant, R., Miracle, A. L., Sun, X., Luer, C. A., Walsh, C. J., Telfer, J. C., Litman, G. W., and Rothenberg, E. V. 2004. Evolutionary origins of lymphocytes: Ensembles of T-cell and B-cell transcriptional regulators in a cartilaginous fish. J. Immunol. 172, 5851-5860.
  96. Rothenberg, E. V. 2004. From totipotency to T in a dish. Nature Immunol. 5, 359-360.
  97. Rothenberg, E. V. and Pant, R. 2004. Origins of lymphocyte developmental programs: Transcription factor evidence. Semin. Immunol. 16, 227-238.
  98. Yui, M. A. and Rothenberg, E. V. 2004. Deranged early T cell development in immunodeficient strains of non-obese diabetic (NOD) mice. J. Immunol. 173, 5381-5391.
  99. Rothenberg, E. V. and Taghon, T. 2005. Molecular genetics of T-cell development. Annu. Rev. Immunol. 23, 601-649.
  100. Dionne, C. J., Tse, K. Y., Weiss, A. H., Franco, C. B., Wiest, D. L., Anderson, M. K., and Rothenberg, E. V. 2005. Subversion of T lineage commitment by PU.1 in a clonal cell line system. Devel. Biol. 280, 448-466.
  101. Rothenberg, E. V. 2005. Thymic regulation – hidden in plain sight. Science 307 (5711), 858-859.
  102. Taghon, T., David, E.-S., Zúñiga-Pflücker, J. C., and Rothenberg, E. V. 2005. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev. 19, 965-978.
  103. Adachi, S., and Rothenberg, E. V. 2005. Cell type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T cells. Nucl. Acids Res. 33, 3200-3210.
  104. Taghon, T., Yui, M. A., Pant, R., Diamond, R. A., and Rothenberg, E. V. 2006. Developmental and molecular characterization of emerging beta- and gamma delta-selected pre-T cells in the adult mouse thymus. Immunity 24, 53-64.
  105. David-Fung, E.-S., Yui, M. A., Morales, M., Wang, H., Taghon, T., Diamond, R. A., and Rothenberg, E. V. 2006. Progression of regulatory gene expression states in fetal and adult pro-T cell development. Immunol. Rev. 209, 212-236.
  106. Wang, D., Claus, C. L., Vaccarelli, G., Braunstein, M., Schmitt, T. M., Zúñiga-Pflücker, J.-C., Rothenberg, E. V., and Anderson, M. K. 2006. The basic helix-loop-helix transcription factor HEBAlt is expressed in pro-T cells and enhances the generation of T cell precursors. J. Immunol. 177, 109-119.
  107. Franco, C. B., Scripture-Adams, D. D., Proekt, I., Taghon, T., Weiss, A. H., Yui, M. A., Adams, S. L., Diamond, R. A., and Rothenberg, E. V. 2006. Notch/Delta signaling constrains re-engineering of pro-T cells by PU.1. Proc. Natl. Acad. Sci. USA 103, 11993-11998.
  108. Rothenberg, E. V. 2007. Cell lineage regulators in B and T cell development. Nat. Immunol. 8, 441-444.
  109. Rothenberg, E. V. 2007. Regulatory factors for initial T-lymphocyte lineage specification. Curr. Opin. Hematol. 14, 322-329.
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